Rotaviruses are the leading cause of severe gastroenteritis and dehydrating diarrhea in
young children and animals worldwide. A murine model and “backpack tumor”
transplantation were used to determine the protective effect of antibodies against VP4 (an
outer capsid viral protein) and VP6 (a major inner capsid viral protein). Only two non-
neutralizing immunoglobulin A (IgA) antibodies to VP6 were capable of preventing primary
and resolving chronic murine rotavirus infections. These antibodies were not active …

Rotaviruses are the leading cause of severe gastroenteritis and dehydrating diarrhea in
young children and animals worldwide. A murine model and" backpack-tumor"
transplantation were used to determine the protective effect of antibodies against VP-4 (an
outer capsid viral protein) and VP-6 (a major inner capsid viral protein).