A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein
aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse.
Therapeutic options are currently being explored that target different steps in the production
and processing of proteins implicated in neurodegenerative disease, including synthesis,
chaperone-assisted folding and trafficking, and degradation via the proteasome and
autophagy pathways. Other therapies, like mTOR inhibitors and activators of the heat shock …

A common pathogenic mechanism shared by diverse neurodegenerative disorders, like
Alzheimer's disease, Parkinson's disease, Huntington's disease and transmissible
spongiform encephalopathies, may be altered protein homeostasis leading to protein
misfolding and aggregation of a wide variety of different proteins in the form of insoluble
fibrils. Mutations in the genes encoding protein constituents of these aggregates have been
linked to the corresponding diseases, thus a reasonable scenario of pathogenesis was …