Methods

In this cross-sectional study, 261 patients with mild-to-very severe COPD (forced expiratory volume in 1 s, 62±25% pred) and 94 age-matched controls (forced expiratory volume in 1 s, 114±14% pred) completed an incremental cycle CPET to determine peak oxygen uptake (VO2peak). Throughout exercise, expired gases, operating lung volumes, and dyspnea intensity were assessed. At peak exercise, dyspnea quality was assessed using a modified 15-item questionnaire.

Results

Logistic regression analysis revealed that among 15 dyspnea descriptors, only those alluding to the cluster" unsatisfied inspiration" were consistently associated with an increased likelihood for both critical inspiratory mechanical constraint (end-inspiratory lung volume/total lung capacity ratio≥ 0.9) during exercise and reduced exercise capacity (VO2peak< lower limit of normal) in COPD (odds ratio (95% confidence interval), 3.26 (1.40-7.60) and 3.04 (1.24-7.45), respectively; both, P< 0.05). Thus, patients reporting" unsatisfied inspiration"(n= 177 (68%)) had an increased relative frequency of critical inspiratory mechanical constraint and low exercise capacity compared with those who did not select this descriptor, regardless of COPD severity or peak dyspnea intensity scores.

Conclusions

In patients with COPD, regardless of disease severity, reporting descriptors in the unsatisfied inspiration cluster complemented traditional assessments of dyspnea during CPET and helped identify patients with critical mechanical abnormalities germane to exercise intolerance.