Radioiodination, nasal nanoformulation and preliminary evaluation of isovanillin: a new potential brain cancer-targeting agent
OA El-Kawy, HA Shweeta, KM Attallah - Applied Radiation and Isotopes, 2022 - Elsevier
Brain cancer is a challenging disease to treat using conventional approaches. The present
investigation aimed to develop a radiopharmaceutical targeting brain cancer based on
natural isovanillin. Different parameters were optimized, resulting in high radiolabeling
efficiency (97.3±1.2%) and good stability (< 48 h). The tracer was formulated for intranasal
delivery in a chitosan nanoparticles system with a mean particle size of 141±2 nm, a
polydispersity index of 0.23±0.02, and a zeta potential of− 17.4±0.3 mV to enhance nasal …
investigation aimed to develop a radiopharmaceutical targeting brain cancer based on
natural isovanillin. Different parameters were optimized, resulting in high radiolabeling
efficiency (97.3±1.2%) and good stability (< 48 h). The tracer was formulated for intranasal
delivery in a chitosan nanoparticles system with a mean particle size of 141±2 nm, a
polydispersity index of 0.23±0.02, and a zeta potential of− 17.4±0.3 mV to enhance nasal …
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