… was refractory to both CD19 CAR T cell and blinatumomab therapies. … CAR-T cells and
dual-target CAR-T cells are available to compare their levels of efficacy, multitarget CAR-T cell …

… We then report on the tools used for production of CAR-T cells. Finally, we address the
challenges posed by CAR-T cells. … Finally, we address the challenges posed by CAR-T cells. …

… engineering strategies are being developed to expand the clinical successes achieved with
CAR T cells to … emerging strategies to engineer safer and more effective CAR T cells for the …

… Chimeric antigen receptor (CAR) T cell therapy has emerged as a novel therapeutic T cell
engineering practice, in which T cells derived from patient blood are engineered in vitro to …

… to deliver both signals 1 and 2 in cis, resulting in T cell activation. The spatial distance
between CAR-T cells and target tumor cells is not known, nor is it known whether this distance is …

… hurdles, new CAR-T cells engineering strategies were designed, … cells to evade immune
defenses and we critically expose the most optimistic engineering strategies to make CAR-T cell …

… applications of CAR-T cells necessitates engineering approaches on multiple … CAR-T cell
therapy by engineering (1) the CAR protein, (2) T cells, and (3) the interaction between T cells …

… This study could pave the way to engineering anti-oxidant producing CAR T cells or using
anti-oxidant agents with CAR T cell therapy in order to overcome the oxidative stress caused …

… and approaches to engineer more powerful CAR-T cells with … recent innovations in CAR-T
cell engineering to improve … strategies to overcome limitations of CAR-T cell therapy in both …

… , which were eventually observed in CAR T cell trials using other CARs encompassing …
lymphoma following a single infusion of human CAR T cells in mice 58 , thus providing the …