Chronic kidney disease (CKD) is a global health epidemic that accelerates cardiovascular
disease, increases risk of infection, and causes anemia and bone disease, among other
complications that collectively increase risk of premature death. Alterations in calcium and
phosphate homeostasis have long been considered nontraditional risk factors for many of
the most morbid outcomes of CKD. The discovery of fibroblast growth factor 23 (FGF23),
which revolutionized the diagnosis and treatment of rare hereditary disorders of FGF23 …