… Notch receptors and their ligands are expressed in the mammalian thymus, raising the …
Notch could regulate T cell fate decisions. Expression of a constitutively activated form of Notch in …

… Notch signal and the current understanding of the role of Notch signal in determining the T
cell fate… Notch signal is essential for regulatory T cells (Tregs) that are known to be involved in …

… that are normally only present in the thymus, and lacked B cell differentiation … , Notch
signaling inhibits the monocyte and B cell fate, promotes the T cell fate, and alters the normal T cell …

… Constraining the non-T cell fates of these progenitors while promoting the T cell fate is a …
normally escape these inhibitory effects of Notch, and adopt non-T cell fates within the thymus. A …

… the Notch … Notch regulates T cell differentiation and function. We review these findings here,
and outline both unifying principles involved in Notch-mediated T cell fate decisions and cell …

… to support a conserved role for Notch in the mediation of cell fate decisions and self-renewal …
of the Notch signaling pathway, evidence regarding Notch function, interactions of the Notch …

… Previous evidence suggested that the Notch signalling pathway, known to play a critical
role in cell fate decision throughout development, has the potential to instruct CD8+ T cell fate …

… to various T cell fates by sensitizing T cells to cytokine-derived and other regulatory signals.
… expression of DNMAML to ablate Notch signalling found that Notch had no impact on Th2 …

… Given recent evidence that regulatory T cell (Treg) effector function is mediated by TGF-β
signaling, … . Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-…

… target genes are studied individually, it is clear that other regulatory inputs are required to …
mouse T cell development 24 . Given that Notch signalling is not sufficient to control human T-…