[HTML] nih.gov

Risk of Alzheimer's disease and related dementia by sex and race/ethnicity: The Multiethnic Cohort Study

U Lim, S Wang, SY Park, D Bogumil… - Alzheimer's & …, 2022 - Wiley Online Library
U Lim, S Wang, SY Park, D Bogumil, AH Wu, I Cheng, CA Haiman, L Le Marchand…
Alzheimer's & Dementia, 2022•Wiley Online Library
Introduction Data are limited for comparison of sex‐and race/ethnicity‐specific risks of
Alzheimer's disease and related dementia (ADRD). Methods In the population‐based
Multiethnic Cohort, we estimated the age‐standardized diagnostic incidence rate (ASDIR)
and relative risk of late‐onset ADRD (n= 16,410) among 105,796 participants based on
Medicare claims (1999‐2014) by sex and race/ethnicity. Results The ASDIR for ADRD was
higher for women (17.0 per 1000 person‐years) than for men (15.3) and varied across …
Introduction
Data are limited for comparison of sex‐ and race/ethnicity‐specific risks of Alzheimer's disease and related dementia (ADRD).
Methods
In the population‐based Multiethnic Cohort, we estimated the age‐standardized diagnostic incidence rate (ASDIR) and relative risk of late‐onset ADRD (n = 16,410) among 105,796 participants based on Medicare claims (1999‐2014) by sex and race/ethnicity.
Results
The ASDIR for ADRD was higher for women (17.0 per 1000 person‐years) than for men (15.3) and varied across African Americans (22.9 in women, 21.5 in men), Native Hawaiians (19.3, 19.4), Latinos (16.8, 14.7), Whites (16.4, 15.5), Japanese Americans (14.8, 13.8), and Filipinos (12.5, 9.7). Similar risk patterns were observed for AD. Adjustment for education and cardiometabolic diseases attenuated the differences. Accounting for deaths from competing causes increased the sex difference, while reducing the racial/ethnic differences. Less racial/ethnic disparity was detected among apolipoprotein E (APOE) e4 carriers.
Discussion
More research is needed to understand the sex and racial/ethnic differences in ADRD.
Wiley Online Library
展开收起
被引用次数：33 相关文章 所有 5 个版本
以上显示的是最相近的搜索结果。 查看全部搜索结果