Major depression remains difficult to treat, despite the wide array of registered
antidepressants available. In recent years there has been a surge in the popularity of natural
or alternative medications. Despite this growing popularity, there is limited evidence for the
effectiveness of many of these natural treatments. S-adenosyl-l-methionine (SAMe) is one of
the better studied of the natural remedies. SAMe is a methyl donor and is involved in the
synthesis of various neurotransmitters in the brain. Derived from the amino acid l-methionine …