… beta-cell function and mass was not clear until the establishment of mice with beta-cell-specific
deletion of VEGF-a … role of VEGF-A in islet function based on studies on RIP-Cre:Vegffl/fl. …

… , that the angiogenesis inducer VEGF-A has a critical, apparently nonredundant role in the
… roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell…

… of the role of vascular endothelial growth factor-A (VEGF-A) and endothelial cells in beta cell
… In addition, the therapeutic potential of modulating VEGF-A levels in beta and beta-like cells …

… By deleting VEGF-A in the mouse pancreas, we show that endocrine cells signal back to the
adjacent endothelial cells … in angiogenic switching and pancreatic beta cell carcinogenesis. …

… of paracrine factors between beta cells and ECs is … , pancreatic beta cell development and
function. In this review, we focus on the beneficial role of VEGFA signaling in driving beta cell …

… First, is VEGF-A release from beta cells coupled to VEGF-A production in beta cells? Second…
, our data suggest that VEGF-A release in beta cells is independent of VEGF-A synthesis. …

… While α and β cells formed islet cell clusters in … cell differentiation and islet cell clustering
in VEGF-A overexpressing embryos. With continued overexpression of VEGF-A, α and β cells …

… development and function. We report, for the first … function study to evaluate the effect of
transient VEGF-A overexpression by adult pancreatic beta cells on islet vasculature and beta cell …

… 18,20]), our genetic data indicate that VEGF-A plays a unique role in islet vascularization.
β-Cell–specific inactivation of VEGF-A led to substantial loss in islet vessel density, vessel size, …

… To investigate the role of VEGF-A and ECs in adult islet function, we used complementary
… inactivate VEGF-A in developing pancreatic and islet progenitors or in adult β-cells using a …