… in heart failure could theoretically affect the calcium sensitivity of … role of the extracellular
matrix for diastolic function in heart failure and the changes in chamber stiffness and myocardial …

… that intracellular calcium … to cardiac dysfunction in various animal models of heart failure,
it remains to be proven that this process plays an important role in causing human heart failure. …

… Thus, defects in RyR2 have been linked to heart failure and exercise-induced sudden cardiac
… (b) To enable relaxation, intracellular Ca 2+ is pumped out of the cytoplasm by the SR …

… OBJECTIVE: The purpose of this study was to investigate … cardiac dysfunction by changes
in intracellular Ca 2+ handling, probably by reduced cardiac sarcoplasmic reticulum Ca 2+ …

… cardiac muscle is calcium-induced calcium release via the RyR (4, 5), evidence has
accumulated supporting a role for IP3-induced calcium … in progressive myocardial dysfunction. …

… + handling has been implicated in cardiac arrhythmias and contractile dysfunction. … Ca 2+
handling, we measured intracellular Ca 2+ transients in isolated intact field-stimulated cardiac …

… overstimulation contributing to myocardial dysfunction could be … that an altered Ca 2+ cycling
plays a dominant role in the … , myocardial infarction, valvular heart disease, or heart failure. …

… systolic Ca 2+ release and SR Ca 2+ load, underlying the depressed cardiac function of wt
… exhibited an ameliorated cardiac dysfunction via an intracellular Ca 2+ handling mechanism (…

… dysfunction is associated with impaired myocardial Ca 2+ … the risk of heart failure in diabetic
patients, despite preserved … -induced intracellular Ca 2+ transients as a function of voltage in …

… Disorders of SR function lead to the dysfunction of Ca 2+ … conditions for the transient
increase of intracellular Ca 2+ . … improved cardiac function in dilated heart disease mice and …