Rutin ameliorates hepatic fibrosis via targeting hepatic stellate cells' activation, proliferation and apoptosis
WH El-Maadawy, SH Seif el-Din, SM Ezzat… - Journal of Herbs …, 2021 - Taylor & Francis
Despite rutin, extracted from black mulberry, has several pharmacological activities, its exact
effect against hepatic fibrosis remains incompletely identified. Accordingly, this study
investigates whether rutin is a promising candidate for treating hepatic fibrosis and to clarify
its underlying antifibrotic mechanisms in vitro and in vivo. In vitro studies were performed on
hepatic stellate cell line (HSC-T6) whereas liver fibrosis was established in rats via chronic
thioacetamide (TAA)-intoxication. Rats were divided into (i) normal,(ii) TAA-intoxicated rats; …
effect against hepatic fibrosis remains incompletely identified. Accordingly, this study
investigates whether rutin is a promising candidate for treating hepatic fibrosis and to clarify
its underlying antifibrotic mechanisms in vitro and in vivo. In vitro studies were performed on
hepatic stellate cell line (HSC-T6) whereas liver fibrosis was established in rats via chronic
thioacetamide (TAA)-intoxication. Rats were divided into (i) normal,(ii) TAA-intoxicated rats; …
[PDF][PDF] Rutin Ameliorates Hepatic Fibrosis via Targeting Hepatic Stellate Cells' Activation, Proliferation and Apoptosis
M Safar - 2021 - buescholar.bue.edu.eg
Despite rutin, extracted from black mulberry, has several pharmacological activities, its exact
effect against hepatic fibrosis remains incompletely identified. Accordingly, this study
investigates whether rutin is a promising candidate for treating hepatic fibrosis and to clarify
its underlying antifibrotic mechanisms in vitro and in vivo. In vitro studies were performed on
hepatic stellate cell line (HSC-T6) whereas liver fibrosis was established in rats via chronic
thioacetamide (TAA)-intoxication. Rats were divided into (i) normal,(ii) TAA-intoxicated rats; …
effect against hepatic fibrosis remains incompletely identified. Accordingly, this study
investigates whether rutin is a promising candidate for treating hepatic fibrosis and to clarify
its underlying antifibrotic mechanisms in vitro and in vivo. In vitro studies were performed on
hepatic stellate cell line (HSC-T6) whereas liver fibrosis was established in rats via chronic
thioacetamide (TAA)-intoxication. Rats were divided into (i) normal,(ii) TAA-intoxicated rats; …
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