SZ‐685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway
G Xie, X Zhu, Q Li, M Gu, Z He, J Wu, J Li… - British journal of …, 2010 - Wiley Online Library
Background and purpose: The aims of this study were to investigate the anti‐cancer activity
of SZ‐685C, an anthracycline analogue isolated from marine‐derived mangrove endophytic
fungi, and to explore the molecular mechanisms underlying such activity. Experimental
approach: The effect of SZ‐685C on the viability of cancer cell lines was investigated using
the 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyl tetrazolium bromide (MTT) assay. SZ‐685C‐
induced apoptosis was assessed by Annexin V‐fluorescein isothiocyanate/propidium iodide …
of SZ‐685C, an anthracycline analogue isolated from marine‐derived mangrove endophytic
fungi, and to explore the molecular mechanisms underlying such activity. Experimental
approach: The effect of SZ‐685C on the viability of cancer cell lines was investigated using
the 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyl tetrazolium bromide (MTT) assay. SZ‐685C‐
induced apoptosis was assessed by Annexin V‐fluorescein isothiocyanate/propidium iodide …
SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway.
XG Xie Gui'e, ZX Zhu Xun, LQ Li Qing… - 2010 - cabidigitallibrary.org
Background and purpose: The aims of this study were to investigate the anti-cancer activity
of SZ-685C, an anthracycline analogue isolated from marine-derived mangrove endophytic
fungi, and to explore the molecular mechanisms underlying such activity. Experimental
approach: The effect of SZ-685C on the viability of cancer cell lines was investigated using
the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. SZ-685C-
induced apoptosis was assessed by Annexin V-fluorescein isothiocyanate/propidium iodide …
of SZ-685C, an anthracycline analogue isolated from marine-derived mangrove endophytic
fungi, and to explore the molecular mechanisms underlying such activity. Experimental
approach: The effect of SZ-685C on the viability of cancer cell lines was investigated using
the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. SZ-685C-
induced apoptosis was assessed by Annexin V-fluorescein isothiocyanate/propidium iodide …
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