Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-γ plus LPS
SII Jang, YJ Kim, WY Lee, KC Kwak, SH Baek… - Archives of pharmacal …, 2005 - Springer
Scoparone is a major component of the shoot of Artemisia capillaris (Compositae), which
has been used for the treatment of hepatitis and biliary tract infection in oriental countries. In
the present study we observed that, scorparone exhibited no cytotoxic effect in unstimulated
macrophages, but reduced the release of nitric oxide (NO) and prostaglandin E 2 (PGE 2)
upon stimulation by IFN-γ/LPS or LPS. The inhibitory effects were found to be in conjuction
with the suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX …
has been used for the treatment of hepatitis and biliary tract infection in oriental countries. In
the present study we observed that, scorparone exhibited no cytotoxic effect in unstimulated
macrophages, but reduced the release of nitric oxide (NO) and prostaglandin E 2 (PGE 2)
upon stimulation by IFN-γ/LPS or LPS. The inhibitory effects were found to be in conjuction
with the suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX …
Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-γ plus LPS.
JSI Jang SeonIl, KYJ Kim YoungJun… - 2005 - cabidigitallibrary.org
Scoparone is a major component of the shoot of Artemisia capillaris (Compositae), which
has been used for the treatment of hepatitis and biliary tract infection in oriental countries. In
the present study we observed that, scorparone exhibited no cytotoxic effect in unstimulated
macrophages, but reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2)
upon stimulation by IFN-γ/LPS or LPS. The inhibitory effects were found to be in conjuction
with the suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX …
has been used for the treatment of hepatitis and biliary tract infection in oriental countries. In
the present study we observed that, scorparone exhibited no cytotoxic effect in unstimulated
macrophages, but reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2)
upon stimulation by IFN-γ/LPS or LPS. The inhibitory effects were found to be in conjuction
with the suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX …
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