Selective hydrolysis of peptides promoted by metal ions: a positional scanning approach
T Bantan-Polak, KB Grant - Chemical communications, 2002 - pubs.rsc.org
T Bantan-Polak, KB Grant
Chemical communications, 2002•pubs.rsc.org… (Conventional methods based on HPLC and NMR have serious limitations that prevent the
simultaneous analysis of multiple hydrolysis reactions.) To this end, we introduce a
fluorescamine-based positional scanning strategy that permits rapid identification of hydrolyzed
amino acid sequences and rapid screening of metal ions and complexes. Positional scanning
represents a powerful combinatorial tool for the identification of enzyme substrates and protein …
simultaneous analysis of multiple hydrolysis reactions.) To this end, we introduce a
fluorescamine-based positional scanning strategy that permits rapid identification of hydrolyzed
amino acid sequences and rapid screening of metal ions and complexes. Positional scanning
represents a powerful combinatorial tool for the identification of enzyme substrates and protein …
Rapid, microplate-based fluorogenic screening of a positional scanning combinatorial library accurately predicts the sequence specificity of metal-assisted peptide hydrolysis.
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