Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis
PL Longo, HPC Artese, MS Rabelo… - Journal of Applied Oral …, 2014 - SciELO Brasil
Journal of Applied Oral Science, 2014•SciELO Brasil
Diabetes has been associated with periodontitis, but the mechanisms through which
periodontal diseases affect the metabolic control remain unclear. Objective: This study
aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 and monocyte
chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic
periodontitis. Material and Methods: Forty two individuals were enrolled in this study and
assigned to one of five groups: diabetes mellitus with inadequate glycemic control and …
periodontal diseases affect the metabolic control remain unclear. Objective: This study
aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 and monocyte
chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic
periodontitis. Material and Methods: Forty two individuals were enrolled in this study and
assigned to one of five groups: diabetes mellitus with inadequate glycemic control and …
Diabetes has been associated with periodontitis, but the mechanisms through which periodontal diseases affect the metabolic control remain unclear.
Objective
This study aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 and monocyte chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic periodontitis.
Material and Methods
Forty two individuals were enrolled in this study and assigned to one of five groups: diabetes mellitus with inadequate glycemic control and periodontitis (DMI+P, n = 10), diabetes mellitus with adequate glycemic control and periodontitis (DMA+P, n = 10), diabetes mellitus without periodontitis (DM, n = 10), periodontitis without diabetes (P, n=6), and neither diabetes nor periodontitis (H, n = 6). Periodontal clinical examination included visible plaque index (PL), gingival bleeding index (GB), probing depth (PD), attachment level (AL) and bleeding on probing (BP). Glycemic control was evaluated by serum concentration of glycated hemoglobin (HbAlc). Inflammatory serum markers IL-8, IL-6 and (MCP-1) were measured by ELISA.
Results
DMI+P and DMA+P groups presented higher PD (p=0.025) and AL (p=0.003) values when compared to the P group. There were no significant differences among groups for IL-6, IL-8 and MCP-1 serum levels.
Conclusions
Although periodontitis was more severe in diabetic patients, the serum levels of the investigated inflammatory markers did not differ among the groups.
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