[HTML][HTML] Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
J Segalés, E Perdiguero, AL Serrano… - Nature …, 2020 - nature.com
A unique property of skeletal muscle is its ability to adapt its mass to changes in activity.
Inactivity, as in disuse or aging, causes atrophy, the loss of muscle mass and strength,
leading to physical incapacity and poor quality of life. Here, through a combination of
transcriptomics and transgenesis, we identify sestrins, a family of stress-inducible metabolic
regulators, as protective factors against muscle wasting. Sestrin expression decreases
during inactivity and its genetic deficiency exacerbates muscle wasting; conversely, sestrin …
Inactivity, as in disuse or aging, causes atrophy, the loss of muscle mass and strength,
leading to physical incapacity and poor quality of life. Here, through a combination of
transcriptomics and transgenesis, we identify sestrins, a family of stress-inducible metabolic
regulators, as protective factors against muscle wasting. Sestrin expression decreases
during inactivity and its genetic deficiency exacerbates muscle wasting; conversely, sestrin …
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
J Segalés Dalmau, E Perdiguero… - Nat Commun. 2020; …, 2020 - repositori.upf.edu
A unique property of skeletal muscle is its ability to adapt its mass to changes in activity.
Inactivity, as in disuse or aging, causes atrophy, the loss of muscle mass and strength,
leading to physical incapacity and poor quality of life. Here, through a combination of
transcriptomics and transgenesis, we identify sestrins, a family of stress-inducible metabolic
regulators, as protective factors against muscle wasting. Sestrin expression decreases
during inactivity and its genetic deficiency exacerbates muscle wasting; conversely, sestrin …
Inactivity, as in disuse or aging, causes atrophy, the loss of muscle mass and strength,
leading to physical incapacity and poor quality of life. Here, through a combination of
transcriptomics and transgenesis, we identify sestrins, a family of stress-inducible metabolic
regulators, as protective factors against muscle wasting. Sestrin expression decreases
during inactivity and its genetic deficiency exacerbates muscle wasting; conversely, sestrin …
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