[HTML][HTML] Signal pathways in the treatment of Alzheimer's disease with traditional Chinese medicine
MR Ding, YJ Qu, B Hu, HM An - Biomedicine & Pharmacotherapy, 2022 - Elsevier
MR Ding, YJ Qu, B Hu, HM An
Biomedicine & Pharmacotherapy, 2022•ElsevierAim of the review This study aimed to reveal the classical signal pathways and important
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD),
and provide support for further investigation on TCM and its active ingredients. Materials and
methods Literature survey was conducted using PubMed, Web of Science, Google Scholar,
CNKI, and other databases, with “Alzheimer's disease,”“traditional Chinese
medicine,”“medicinal herb,”“Chinese herb,” and “natural plant” as the primary keywords …
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD),
and provide support for further investigation on TCM and its active ingredients. Materials and
methods Literature survey was conducted using PubMed, Web of Science, Google Scholar,
CNKI, and other databases, with “Alzheimer's disease,”“traditional Chinese
medicine,”“medicinal herb,”“Chinese herb,” and “natural plant” as the primary keywords …
Aim of the review
This study aimed to reveal the classical signal pathways and important potential targets of traditional Chinese medicine (TCM) for treating Alzheimer’s disease (AD), and provide support for further investigation on TCM and its active ingredients.
Materials and methods
Literature survey was conducted using PubMed, Web of Science, Google Scholar, CNKI, and other databases, with “Alzheimer’s disease,” “traditional Chinese medicine,” “medicinal herb,” “Chinese herb,” and “natural plant” as the primary keywords.
Results
TCM could modulate signal pathways related to AD pathological progression, including NF-κB, Nrf2, JAK/STAT, ubiquitin-proteasome pathway, autophagy-lysosome pathway-related AMPK/mTOR, GSK-3/mTOR, and PI3K/Akt/mTOR, as well as SIRT1 and PPARα pathway. It could regulate crosstalk between pathways through a multitarget, thus maintaining chronic inflammatory interaction balance, inhibiting oxidative stress damage, regulating ubiquitin-proteasome system function, modulating autophagy, and eventually improving cognitive impairment in patients with AD.
Conclusion
TCM could be multilevel, multitargeted, and multifaceted to prevent and treat AD. In-depth research on the prevention and treatment of AD with TCM could provide new ideas for exploring the pathogenesis of AD and developing new anti-AD drugs.
Elsevier
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