Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in …
C Russo, V Dolcini, S Salis, V Venezia… - Journal of Biological …, 2002 - ASBMB
The proteolytic processing of amyloid precursor protein (APP) through the formation of
membrane-bound C-terminal fragments (CTFs) and of soluble β-amyloid peptides likely
influences the development of Alzheimer's disease (AD). We show that in human brain a
subset of CTFs are tyrosine-phosphorylated and form stable complexes with the adaptor
protein ShcA. Grb2 is also part of these complexes, which are present in higher amounts in
AD than in control brains. ShcA immunoreactivity is also greatly enhanced in patients with …
membrane-bound C-terminal fragments (CTFs) and of soluble β-amyloid peptides likely
influences the development of Alzheimer's disease (AD). We show that in human brain a
subset of CTFs are tyrosine-phosphorylated and form stable complexes with the adaptor
protein ShcA. Grb2 is also part of these complexes, which are present in higher amounts in
AD than in control brains. ShcA immunoreactivity is also greatly enhanced in patients with …
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