Single and multiple administration of a new triphasic oral contraceptive to women: Pharmacokinetics of ethin l estradiol and free and total testosterone levels in serum
W Kuhnz, D Sostarek, C Gansau, T Louton… - American journal of …, 1991 - Elsevier
Ethinyl estradiol is part of almost every combined oral contraceptive, and its pharmacokinetic
characteristics have been thoroughly investigated in numerous studies. However, little is
known about its pharmacokinetics during long-term administration, as compared with single-
dose administration. In this study 10 women received a triphasic formulation that contained
ethinyl estradiol together with the progestin gestodene over one treatment cycle. Mean area
under the curve values of ethinyl estradiol were significantly higher on the last treatment day …
characteristics have been thoroughly investigated in numerous studies. However, little is
known about its pharmacokinetics during long-term administration, as compared with single-
dose administration. In this study 10 women received a triphasic formulation that contained
ethinyl estradiol together with the progestin gestodene over one treatment cycle. Mean area
under the curve values of ethinyl estradiol were significantly higher on the last treatment day …
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