Sleep deprivation therapy (SDT), also referred to as “wake therapy,” is a robust, rapid-acting (within 24–48 hours), noninvasive antidepressant treatment. First proposed by Schulte1 and Pflug and Tolle, 2 SDT has been administered to more than 2000 patients worldwide. One night of enforced sleep loss significantly decreases depressive symptoms in approximately 40%–60% of depressed patients and can be administered as an adjunctive treatment to ongoing medications. 3 Although SDT is relatively safe, there is a slight risk of switches into hypomania/mania that is comparable to or lower than that associated with conventional antidepressants. Mood stabilizers can quickly reverse symptoms in order to restore euthymia. 4–6