This paper investigates the socio-cultural challenges of the small-scale batik and tie-dye production and retailing industry in Ghana. The research is based on a qualitative research approach that employs interviews and observation for data collection. In all, sixteen (16) participants were sampled through purposive techniques. Data collected were transcribed, classified and analysed through thematic and descriptive analysis. The study found that family roles contradict the business role, pressure from family members, poor support from society members, some religious teachings, age, ethnicity and lifestyle of certain people among others. The study concludes that socio-cultural challenges have led to the collapse of most batik and tie-dye production and retailing sectors leaving thousands of Ghanaians jobless. It recommends among others that producers and retailers of batik and tie-dye must separate family roles from work responsibilities to enable them to perform effectively. Again, family members, parents and peers must desist from putting pressure on the entrepreneurs for freebies and the government must resource NBSSI, GEPA and GSB to have regular in-service training to batik and tie-dye producers and retailers to address poor financial management and technical challenges and also on product quality on the international market.