[HTML][HTML] Solid-state NMR spectroscopy identifies three classes of lipids in Cryptococcus neoformans melanized cell walls and whole fungal cells
A primary virulence-associated trait of the opportunistic fungal pathogen Cryptococcus
neoformans is the production of melanin pigments that are deposited into the cell wall and
interfere with the host immune response. Previously, our solid-state NMR studies of isolated
melanized cell walls (melanin" ghosts") revealed that the pigments are strongly associated
with lipids, but their identities, origins, and potential roles were undetermined. Herein, we
exploited spectral editing techniques to identify and quantify the lipid molecules associated …
neoformans is the production of melanin pigments that are deposited into the cell wall and
interfere with the host immune response. Previously, our solid-state NMR studies of isolated
melanized cell walls (melanin" ghosts") revealed that the pigments are strongly associated
with lipids, but their identities, origins, and potential roles were undetermined. Herein, we
exploited spectral editing techniques to identify and quantify the lipid molecules associated …
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