Spinal cord stimulation paradigms and pain relief: a preclinical systematic review on modulation of the central inflammatory response in neuropathic pain
TJ de Geus, G Franken, EAJ Joosten - Neuromodulation: Technology at the …, 2023 - Elsevier
Objectives Spinal cord stimulation (SCS) is a last-resort treatment for patients with chronic
neuropathic pain. The mechanism underlying SCS and pain relief is not yet fully understood.
Because the inflammatory balance between pro-and anti-inflammatory molecules in the
spinal nociceptive network is pivotal in the development and maintenance of neuropathic
pain, the working mechanism of SCS is suggested to be related to the modulation of this
balance. The aim of this systematic review is to summarize and understand the effects of …
neuropathic pain. The mechanism underlying SCS and pain relief is not yet fully understood.
Because the inflammatory balance between pro-and anti-inflammatory molecules in the
spinal nociceptive network is pivotal in the development and maintenance of neuropathic
pain, the working mechanism of SCS is suggested to be related to the modulation of this
balance. The aim of this systematic review is to summarize and understand the effects of …
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