BACKGROUND: A preliminary report in six patients suggested that deep brain stimulation
(DBS) of the subcallosal cingulate gyrus (SCG) may provide benefit in treatment-resistant
depression (TRD). We now report the results of these and an additional 14 patients with
extended follow-up. METHODS: Twenty patients with TRD underwent serial assessments
before and after SCG DBS. We determined the percentage of patients who achieved a
response (50% or greater reduction in the 17-item Hamilton Rating Scale for Depression …

Background: A preliminary report in six patients suggested that deep brain stimulation (DBS)
of the subcallosal cingulate gyrus (SCG) may provide benefit in treatment-resistant
depression (TRD). We now report the results of these and an additional 14 patients with
extended follow-up. Methods: Twenty patients with TRD underwent serial assessments
before and after SCG DBS. We determined the percentage of patients who achieved a
response (50% or greater reduction in the 17-item Hamilton Rating Scale for Depression …