Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process
JY Choi, M Khansaheb, NS Joo… - The Journal of …, 2009 - Am Soc Clin Investig
Chronic bacterial airway infections are the major cause of mortality in cystic fibrosis (CF).
Normal airway defenses include reflex stimulation of submucosal gland mucus secretion by
sensory neurons that release substance P (SubP). CFTR is an anion channel involved in
fluid secretion and mutated in CF; the role of CFTR in secretions stimulated by SubP is
unknown. We used optical methods to measure SubP-mediated secretion from human
submucosal glands in lung transplant tissue. Glands from control but not CF subjects …
Normal airway defenses include reflex stimulation of submucosal gland mucus secretion by
sensory neurons that release substance P (SubP). CFTR is an anion channel involved in
fluid secretion and mutated in CF; the role of CFTR in secretions stimulated by SubP is
unknown. We used optical methods to measure SubP-mediated secretion from human
submucosal glands in lung transplant tissue. Glands from control but not CF subjects …
[HTML][HTML] Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process
JY Choi, M Khansaheb, NS Joo… - The Journal of …, 2010 - Am Soc Clin Investig
Chronic bacterial airway infections are the major cause of mortality in cystic fibrosis (CF).
Normal airway defenses include reflex stimulation of submucosal gland mucus secretion by
sensory neurons that release substance P (SubP). CFTR is an anion channel involved in
fluid secretion and mutated in CF; the role of CFTR in secretions stimulated by SubP is
unknown. We used optical methods to measure SubP-mediated secretion from human
submucosal glands in lung transplant tissue. Glands from control but not CF subjects …
Normal airway defenses include reflex stimulation of submucosal gland mucus secretion by
sensory neurons that release substance P (SubP). CFTR is an anion channel involved in
fluid secretion and mutated in CF; the role of CFTR in secretions stimulated by SubP is
unknown. We used optical methods to measure SubP-mediated secretion from human
submucosal glands in lung transplant tissue. Glands from control but not CF subjects …
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