Nanoparticles have distinct properties that make them potentially valuable in a variety of industries. As a result, emerging approaches for the manufacture of nanoparticles are gaining a lot of scientific interest. The biological pathway of nanoparticle synthesis has been suggested as an effective, affordable, and environmentally safe method. Synthesis of nanoparticles through physical and chemical processes uses unsafe materials, expensive equipment and adversely affects the environment. As a result, in order to support the increased utilization of nanoparticles across many sectors, nanotechnology research activities have shifted toward environmentally safe and cost-effective techniques that outperform chemical and/or biological procedures. The use of organisms to produce metal nanoparticles is among the most frequently discussed methods. Plants appear to be the best candidates among these organisms for large-scale nanoparticle biosynthesis. Medicinal plants have been employed as reducing agents and NP stabilizers to minimize the toxicity of NPs in both the environment and the human body. Furthermore, the presence of certain functional components in plant extracts may be extremely useful and effective for the human body. Polyphenol, for example, which may have antioxidant properties, might intercept free radicals before they interact with other biomolecules and cause considerable damage. The current article analyzes the most recent developments and improvements in the green synthesis of metal nanoparticles by different plants and the use of these nanoparticles for various biomedical applications and hopes to provide insights into this exciting research frontier.