TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

M Sulak, L Fong, K Mika, S Chigurupati, L Yon… - elife, 2016 - elifesciences.org
… through time and gathered data on ancient Proboscidean body sizes from … increase in
TP53/TP53RTG copy number in the Proboscidean lineage and Proboscidean body size evolution

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

S Michael, F Lindsey, M Katelyn, C Sravanthi… - … - nottingham-repository.worktribe.com
… through time and gathered data on ancient Proboscidean body sizes from … increase in TP53/
TP53RTG copy number in the Proboscidean lineage and Proboscidean body size evolution

Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

M Sulak, L Fong, K Mika, S Chigurupati, L Yon… - Elife, 2016 - elifesciences.org
… The Proboscidean body size citation was incorrectly cited as ‘Proboscidean body size
data were obtained from previously published studies on mammalian body size evolution (Chen …

The Role of TP53 in Adaptation and Evolution

K Voskarides, N Giannopoulou - Cells, 2023 - mdpi.com
… that p53 null alleles or p53 functional variants are related to … (2016) [62] expanded this
research by including more … Analysis of TP53 copy numbers in multiple species can be seen in …

[HTML][HTML] High levels of chromosomal copy number alterations and TP53 mutations correlate with poor outcome in younger breast cancer patients

A Koçak, K Heselmeyer-Haddad, A Lischka… - The American Journal of …, 2020 - Elsevier
… This study shows that TP53 mutations and the extent of genomic imbalances are associated
with … The arrows indicate the clonal evolution according to gain and loss patterns in the color …

Cancer suppression and the evolution of multiple retrogene copies of TP53 in elephants: A re‐evaluation

L Nunney - Evolutionary applications, 2022 - Wiley Online Library
… The discussion of the TP53 expansion in the elephant has … the correlation of duplicate number
with body size breaks down in … This predicted gain could have involved an increase in p53

The evolution of human cancer gene duplications across mammals

M Tollis, AK Schneider-Utaka… - … biology and evolution, 2020 - academic.oup.com
… This study is the first to investigate cancer gene expansions … For instance, we detected 13
copies of TP53 in the African … gene copy number actually does not increase with body size. …

p53: 800 million years of evolution and 40 years of discovery

AJ Levine - Nature Reviews Cancer, 2020 - nature.com
involved in a range of downstream cellular processes, as well as genes involved in positively
or negatively regulating p53 and/or p53-… of TP53 mutations leading to clonal expansion of …

Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma

S Zhao, M Choi, JD Overton… - Proceedings of the …, 2013 - National Acad Sciences
… losses that occurred more often than expected by chance. In addition to loss of TP53, we …
and endometrioid in histology, are associated with a history of hyperestrogenism, and typically …

miRNAs copy number variations repertoire as hallmark indicator of cancer species predisposition

C Vischioni, F Bove, M De Chiara, F Mandreoli… - Genes, 2022 - mdpi.com
… identified novel gene targets linked to tumor predisposition, … , such as the amplification of
TP53 and pseudogenes [12,15], … bigger sizes and longer lifespans have an expanded number