TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
… through time and gathered data on ancient Proboscidean body sizes from … increase in
TP53/TP53RTG copy number in the Proboscidean lineage and Proboscidean body size evolution …
TP53/TP53RTG copy number in the Proboscidean lineage and Proboscidean body size evolution …
TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
S Michael, F Lindsey, M Katelyn, C Sravanthi… - … - nottingham-repository.worktribe.com
… through time and gathered data on ancient Proboscidean body sizes from … increase in TP53/
TP53RTG copy number in the Proboscidean lineage and Proboscidean body size evolution …
TP53RTG copy number in the Proboscidean lineage and Proboscidean body size evolution …
Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
… The Proboscidean body size citation was incorrectly cited as ‘Proboscidean body size
data were obtained from previously published studies on mammalian body size evolution (Chen …
data were obtained from previously published studies on mammalian body size evolution (Chen …
The Role of TP53 in Adaptation and Evolution
K Voskarides, N Giannopoulou - Cells, 2023 - mdpi.com
… that p53 null alleles or p53 functional variants are related to … (2016) [62] expanded this
research by including more … Analysis of TP53 copy numbers in multiple species can be seen in …
research by including more … Analysis of TP53 copy numbers in multiple species can be seen in …
[HTML][HTML] High levels of chromosomal copy number alterations and TP53 mutations correlate with poor outcome in younger breast cancer patients
A Koçak, K Heselmeyer-Haddad, A Lischka… - The American Journal of …, 2020 - Elsevier
… This study shows that TP53 mutations and the extent of genomic imbalances are associated
with … The arrows indicate the clonal evolution according to gain and loss patterns in the color …
with … The arrows indicate the clonal evolution according to gain and loss patterns in the color …
Cancer suppression and the evolution of multiple retrogene copies of TP53 in elephants: A re‐evaluation
L Nunney - Evolutionary applications, 2022 - Wiley Online Library
… The discussion of the TP53 expansion in the elephant has … the correlation of duplicate number
with body size breaks down in … This predicted gain could have involved an increase in p53 …
with body size breaks down in … This predicted gain could have involved an increase in p53 …
The evolution of human cancer gene duplications across mammals
M Tollis, AK Schneider-Utaka… - … biology and evolution, 2020 - academic.oup.com
… This study is the first to investigate cancer gene expansions … For instance, we detected 13
copies of TP53 in the African … gene copy number actually does not increase with body size. …
copies of TP53 in the African … gene copy number actually does not increase with body size. …
p53: 800 million years of evolution and 40 years of discovery
AJ Levine - Nature Reviews Cancer, 2020 - nature.com
… involved in a range of downstream cellular processes, as well as genes involved in positively
or negatively regulating p53 and/or p53-… of TP53 mutations leading to clonal expansion of …
or negatively regulating p53 and/or p53-… of TP53 mutations leading to clonal expansion of …
Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma
… losses that occurred more often than expected by chance. In addition to loss of TP53, we …
and endometrioid in histology, are associated with a history of hyperestrogenism, and typically …
and endometrioid in histology, are associated with a history of hyperestrogenism, and typically …
miRNAs copy number variations repertoire as hallmark indicator of cancer species predisposition
… identified novel gene targets linked to tumor predisposition, … , such as the amplification of
TP53 and pseudogenes [12,15], … bigger sizes and longer lifespans have an expanded number …
TP53 and pseudogenes [12,15], … bigger sizes and longer lifespans have an expanded number …