… approaching cancer therapy with an eye to the inhibition of TGFβ signaling. TGFβ SIGNALING:
… years promise to better our understanding of targeting TGFβ signaling for cancer therapy. …

… for targeting TGF-β signaling in cancer and … TGF-β signaling blockade on tumor and stromal
cells, as well as biomarkers that can predict the efficacy of TGF-β inhibitors in cancer patients…

… suppression and promotion by TGF-β. In the last part of the review, the data on targeting
TGF-β pathway for cancer treatment is assessed. The TGF-β inhibitors in pre-clinical studies, …

… to TGF-β signaling. The clinical studies under way have already shown TGF-β as a promising
target for cancer therapy… be a powerful means to enhance the outcomes of these therapies. …

… data on targeting TGF-β pathway for cancer treatment is … -TGF-β based treatment and other
options targeting activated pathways in tumors where the TGF-β tumor suppressor pathway is …

… signaling in the regulation of tumorigenesis and we will dissect how targeting the TGF-!
pathway may contribute to fight against cancer. Keywords: …

… of TGF-β and its downstream molecules in the progression of fibrosis and cancers, therapeutics
targeting TGF-β signaling … , the development of TGF-β therapeutics has lagged. In this …

… targeted strategy. In this review, we focus on the TGFβ pathway as a target for cancer therapy…
of the roles played by this pathway and its deregulation in cancer, at the cancer cell and …

… is often elevated in human tumors, and thus a clinical target. This has led to the development
of a range of anti-TGF-β-signaling drugs for cancer therapy. The four major classes of TGF-…

… Transforming growth factor β (TGFβ) was initially discovered acting as an oncogene in
the … its potential as a target for cancer therapy. Subsequent studies showed that TGFβ is a …