Temperature and pH sensitive multi-functional magnetic nanocomposite for the controlled delivery of 5-fluorouracil, an anticancer drug
TS Anirudhan, J Christa - Journal of Drug Delivery Science and Technology, 2020 - Elsevier
With the purpose of avoiding leakage of drug during blood circulation and burst release of
the drug at the tumor site, a functionalized magnetic Fe 3 O 4 drug delivery system (DDS)
with pH and temperature sensitivity was developed for the controlled delivery of 5-
fluorouracil (5FU). Fe 3 O 4 nanoparticles were coated with glycidyl methacrylate grafted
dextran and then N-vinylcaprolactam and N-vinylimidazole monomers were used for further
modification so as to introduce temperature and pH sensitivity respectively. The drug release …
the drug at the tumor site, a functionalized magnetic Fe 3 O 4 drug delivery system (DDS)
with pH and temperature sensitivity was developed for the controlled delivery of 5-
fluorouracil (5FU). Fe 3 O 4 nanoparticles were coated with glycidyl methacrylate grafted
dextran and then N-vinylcaprolactam and N-vinylimidazole monomers were used for further
modification so as to introduce temperature and pH sensitivity respectively. The drug release …
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