The adaptor protein BLNK is required for B cell antigen receptor-induced activation of nuclear factor-κB and cell cycle entry and survival of B lymphocytes
B lymphocytes lacking the adaptor protein B cell linker (BLNK) do not proliferate in response
to B cell antigen receptor (BCR) engagement. We demonstrate here that BCR-activated
BLNK−/− B cells fail to enter the cell cycle, and this is due to their inability to induce the
expression of the cell cycle regulatory proteins such as cyclin D2 and cyclin-dependent
kinase 4. BCR-stimulated BLNK−/− B cells also do not up-regulate the cell survival protein
Bcl-x L, which may be necessary for the cells to complete the cell cycle. In addition, BLNK …
to B cell antigen receptor (BCR) engagement. We demonstrate here that BCR-activated
BLNK−/− B cells fail to enter the cell cycle, and this is due to their inability to induce the
expression of the cell cycle regulatory proteins such as cyclin D2 and cyclin-dependent
kinase 4. BCR-stimulated BLNK−/− B cells also do not up-regulate the cell survival protein
Bcl-x L, which may be necessary for the cells to complete the cell cycle. In addition, BLNK …
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