The apolipoprotein (a) gene: linkage disequilibria at three loci differs in African Americans and Caucasians

J Rubin, HJ Kim, TA Pearson, S Holleran, L Berglund… - Atherosclerosis, 2008 - Elsevier
Lipoprotein (a)(Lp (a)) is an independent, genetically regulated cardiovascular risk factor. Lp
(a) plasma levels are largely determined by the apolipoprotein (a)(apo (a)) component, and
differ across ethnicity. Although a number of polymorphisms in the apo (a) gene have been
identified, apo (a) genetic regulation is not fully understood. To study the relation between
apo (a) gene variants, we constructed haplotypes and assessed linkage equilibrium in
African Americans and Caucasians for three widely studied apo (a) gene polymorphisms …
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