The biology of chronic myeloid leukemia

S Faderl, M Talpaz, Z Estrov, S O'Brien… - … England Journal of …, 1999 - Mass Medical Soc
Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of transformed,
primitive hematopoietic progenitor cells. It involves myeloid, monocytic, erythroid, …

The molecular biology of chronic myeloid leukemia

MWN Deininger, JM Goldman… - Blood, The Journal of the …, 2000 - ashpublications.org
Chronic myeloid leukemia (CML) is probably the most extensively studied human malignancy.
The discovery of the Philadelphia (Ph) chromosome in 19601 as the first consistent …

Molecular biology of chronic myeloid leukemia

Y Maru - Cancer science, 2012 - Wiley Online Library
… ‐apoptosis, metabolism and stemness, has made the study of chronic myeloid leukemia
the most successful field in tumor biology. However, we now face the issue of drug resistance …

Biology of chronic myelogenous leukemia

CM Verfaillie - Hematology/oncology clinics of North America, 1998 - Elsevier
Chronic myelogenous leukemia (CML) is a malignant disease of the human hematopoietic
stem cell. The disease is characterized by an abnormal expansion of granulocytic progenitors …

Biology of chronic myelogenous leukemia—signaling pathways of initiation and transformation

JV Melo, MWN Deininger - Hematology/Oncology Clinics, 2004 - hemonc.theclinics.com
… breakpoint in chronic myeloid leukemia with poor outcome. Leukemia. 2003; 17: 1313-1323 …
(e6a2) in a patient with Philadelphia chromosome negative chronic myelogenous leukemia. …

Chronic myeloid leukemia

CL Sawyers - New England Journal of Medicine, 1999 - Mass Medical Soc
… In the past decade clinical and laboratory studies have led to important new insights into
the biology of chronic myeloid leukemia (CML). Basic science has defined the molecular …

New insights into biology of chronic myeloid leukemia: implications in therapy

M Cea, A Cagnetta, A Nencioni… - Current cancer drug …, 2013 - ingentaconnect.com
Over the past decades the prognosis of patients with Chronic Myeloid Leukemia (CML) has
radically changed due to groundbreaking scientific and translational studies that have …

Chronic myelogenous leukemia: biology and therapy

S Faderl, M Talpaz, Z Estrov… - Annals of internal …, 1999 - acpjournals.org
… promise for the cure of chronic myelogenous leukemia. Chronic myelogenous leukemia is
a … the clinically relevant biology and treatment advances in chronic myelogenous leukemia. …

Chronic myeloid leukemia

JV Melo, TP Hughes, JF Apperley - ASH Education Program …, 2003 - ashpublications.org
… In this report, we discuss the biological basis for such translation and highlight the current
and potential tools for the effective treatment of CML patients. The first part presents a review of …

Chronic myeloid leukemia

H Kantarjian, J Cortes, E Jabbour… - Molecular …, 2019 - Wiley Online Library
… Center long-term experience of chronic myeloid leukemia … Induction of chronic myelogenous
leukemia in mice by the … The molecular biology of chronic myeloid leukemia. Blood 96…