Captopril (SQ 14,225)(D-3-mercapto-2-methylpropanoyl-L-proline): a novel orally active inhibitor of angiotensin-converting enzyme and antihypertensive agent

B Rubin, MJ Antonaccio, ZP Horovitz - Progress in cardiovascular diseases, 1978 - Elsevier
… , captopril persisted in significantly reducing blood pressureCaptopril also lowered blood
pressure in intact dogs … were found as blood pressure was lowered; total peripheral vascular …

Effects of chronic treatment with captopril (sq 14, 225), an orally active inhibitor of angiotensin i-converting enzyme, in spontaneously hypertensive rats

MJ Antonaccio, B RUBIN, ZP HOROVITZ… - The Japanese Journal …, 1979 - jstage.jst.go.jp
… inhibitor captopril (SQ 14,225) (100 mg/kg) on mean arterial blood … , captopril possesses no
other apparent acute peripheral … that captopril reduces mean arterial blood pressure of SHR. …

Effects of long-term blockade of angiotensin converting enzyme with captopril (SQ14, 225) on hemodynamics and circulating blood volume in SHR.

H Koike, K Ito, M Miyamoto, H Nishino - Hypertension, 1980 - Am Heart Assoc
… , received oral administration of captopril (SQ 14,225) daily at a dose of … captopril, mean
blood pressure decreased and CO increased in a dose-dependent manner; thus total peripheral

Chronic antihypertensive effects of captopril (SQ 14,225), an orally active angiotensin I-converting enzyme inhibitor, in conscious 2-kidney renal hypertensive rats

B Rubin, MJ Antonaccio, ME Goldberg… - European Journal of …, 1978 - Elsevier
… In contrast, return of blood pressure to pre-drug levels after cessation of captopril dosage
required from 5 to 7 days. The reason for these differences in onset and duration of action of …

ANALYSIS OF THE MECHANISM OF ACUTE DECREASE OF BLOOD PRESSURE INDUCED BY CAPTOPRIL (SQ 14, 225) IN DOGS BY THE USE OF APROTININ …

N Ohara, H Ono, K Hashimoto - Japanese Circulation Journal, 1981 - jstage.jst.go.jp
captopril (SQ 14225), an angiotensin converting enzyme (ACE) inhibitor, effectively decreased
blood pressure in … et al.22 reported that captopril-induced reduction of peripheral vascular …

Hemodynamic effects of captopril in patients with severe chronic heart failure

TH Lejemtel, E Keung, WH Frishman, HS Ribner… - The American Journal of …, 1982 - Elsevier
… The hemodynamic effects of captopril (SO 14225), an oral … in blood pressure occurred
after the first 25 mg of captopril, … Central and peripheral hemodynamic effects of angiotensin …

Prevention of the development of spontaneous hypertension in rats by captopril (SQ 14,225)

RA Ferrone, MJ Antonaccio - European journal of pharmacology, 1979 - Elsevier
… Share and ZP Horovitz, 1979, The effects of SQ 14,225 on systolic blood pressure and …
Steinbach, 1976, Blood pressure response to central and peripheral injection of angiotensin …

Long-term treatment of congestive heart failure by captopril: hemodynamic, biological and clinical effects

JG Kayanakis, JM Fauvel, P Giraud… - European Heart …, 1981 - academic.oup.com
… , biological and hemodynamic effects of Captopril (SQ 14225), an … play an important role in
Captopril peripheral vasodilator action. … Long-term effects of Captopril on blood pressure and …

Antihypertensive effects of angiotensin blockade: saralasin versus captopril

KM Baker, DW Johns, ED Vaughan… - Clinical and …, 1980 - Taylor & Francis
… angiotensin I1 antagonist, and captopril (SQ 14225), a competitive … decrease in blood pressure
with captopril. The difference in … A baseline two hour upright peripheral vein blood sample …

Captopril (Capoten®; SQ 14,225) (d-3-Mercapto-2-methylpropanoyl-l-proline) A Novel Orally Active Inhibitor of Angiotensin-Converting Enzyme and …

B Rubin, MJ Antonaccio, ZP Horovitz - Captopril and Hypertension, 1980 - Springer
… , captopril persisted in significantly reducing blood pressureCaptopril also lowered blood
pressure in intact dogs … were found as blood pressure was lowered; total peripheral vascular …