Captopril: a preliminary review of its pharmacological properties and therapeutic efficacy

RC Heel, RN Brogden, TM Speight, GS Avery - Drugs, 1980 - Springer
… of all the effects described above to the blood pressure-lowering effect of Captopril is the …
is probably of major importance to captopril’s blood pressure-lowering effect, it is not clear …

Central and peripheral contributions of the renin-angiotensin system in two models experimental hypertension in rats

H Suzuki, S Matsukawa, Y Itaya… - … Hypertension. Part A …, 1986 - Taylor & Francis
… Also, the effects of IVT captopril on the peripheral sympathetic … captopril induced a significant
reduction of blood pressureeffects of IV captoprii not IV prazosin following IVT captopril

Cardiovascular effects and regional blood flow distribution associated with angiotensin converting enzyme inhibition (captopril) in essential hypertension

HO Ventura, ED Frohlich, FH Messerli, I Kobrin… - The American journal of …, 1985 - Elsevier
… Thus, captopril lowered arterial pressure through systemic … that captopril most likely
produces its peripheral arteriolar … effect of the oral angiotensin converting enzyme inhibitor SQ

MEAN 180 ARTERIAL 160 PRESSURE 140 120 mmHg 100

DB Young - Frontiers in Hypertension Research, 2012 - books.google.com
… 2, 20 mg captopril (SQ 14225) were given as an iv bolus. … Captopril had no effect on
arterial pressure on the final day of … its effect via a central neural effect resulting in peripheral

Peripheral hemodynamic effects of captopril in patients with congestive heart failure

H Nishimura, S Kubo, M Ueyama, J Kubota… - American Heart …, 1989 - Elsevier
… a single dose of captopril (25 mg), mean blood pressure and venous pressure decreased (p
Central cardiovascular effects of SQ 14,225, an angiotensin-converting enzyme inhibitor in …

Effects of captopril on vascular noradrenergic transmission in SHR.

DC Eikenburg - Hypertension, 1984 - Am Heart Assoc
… study, captopril failed to significantly lower blood pressure in … in SHR can be attributed to
a decrease in peripheral resis… Antihypertensive activity in rats of SQ 14,225, an orally active …

Captopril: pharmacology, metabolism, and disposition

BH Migdalof, MJ Antonaccio, DN Mc Kinstry… - Drug metabolism …, 1984 - Taylor & Francis
… as angiotensin I (AI) or peptide inhibitors such as SQ 20,881. … reduction in blood pressure
when combined with captopril. … in blood pressure resulted from a reduction in total peripheral

Prevention of hypertension and vascular changes by captopril treatment.

RM Lee, KH Berecek, J Tsoporis, R McKenzie… - …, 1991 - Am Heart Assoc
Blood pressure in the captopriltreated SHR was similar to that in the untreated WKY rats;
however, blood pressure … of spontaneous hypertension in rats by captopril (SQ 14,225). Eur J …

In vivo comparison of three orally active inhibitors of angiotensin-converting enzyme

Y Takata, R Dinicolantonio, JS Hutchinson… - The American Journal of …, 1982 - Elsevier
… (SQ 14225 [captopril], SA 446 and MK 421) as inhibitors of angiotensin l-converting enzyme
in vivo and to compare their effects on blood pressureperipheral administration of captopril. …

Dilation of forearm blood vessels after angiotensin-converting-enzyme inhibition by captopril in hypertensive patients.

DW Johns, CR Ayers, SC Williams - Hypertension, 1984 - Am Heart Assoc
… a greater reduction in BP and peripheral resistance than … to lower blood pressure did not
inhibit captopril's ability to lower … enzyme inhibitor (SQ 14225, captopril) in hypertensive patients…