The cerebral pharmacokinetics of meperidine and alfentanil in conscious sheep
RN Upton, GL Ludbrook, EC Gray… - The Journal of the …, 1997 - pubs.asahq.org
… sheep in the current study during the first few minutes after administration of meperidine or
alfentanil… with stimulation was previously recorded in awake sheep, [13] and the time course …
alfentanil… with stimulation was previously recorded in awake sheep, [13] and the time course …
Cerebral kinetics of oxycodone in conscious sheep
HH Villesen, DJR Foster, RN Upton… - Journal of …, 2006 - Elsevier
… In conclusion, pharmacokinetic modelling of oxycodone … In contrast, morphine has a small
cerebral distribution volume … to determine the cerebral kinetics of other opioids (eg alfentanil, …
cerebral distribution volume … to determine the cerebral kinetics of other opioids (eg alfentanil, …
Cerebral and lung kinetics of morphine in conscious sheep after short intravenous infusions
RN Upton, GL Ludbrook, AM Martinez… - British journal of …, 2003 - academic.oup.com
… Cerebral pharmacokinetics were determined from simultaneous measurements of arterial
… experimental conditions in conscious instrumented sheep. Data for alfentanil and pethidine …
… experimental conditions in conscious instrumented sheep. Data for alfentanil and pethidine …
A comparison of pharmacokinetic/pharmacodynamic versus mass-balance measurement of brain concentrations of intravenous anesthetics in sheep
… We compared the pharmacokinetic/pharmacodynamic and mass-balance methods for propofol,
methohexital, and ketamine in a sheep model. Both methods give similar values for t ½ K …
methohexital, and ketamine in a sheep model. Both methods give similar values for t ½ K …
Pharmacokinetics of human cerebral opioid extraction: a comparative study on sufentanil, fentanyl, and alfentanil in a patient after severe head injury
C Metz, L Göbel, M Gruber, KH Hoerauf… - The Journal of the …, 2000 - pubs.asahq.org
… In conscious sheep, the half-lives of equilibrium between blood and brain were 0.8 and 6.3
min for alfentanil and meperidine, … Upton et al. 10found that large differences in the cerebral …
min for alfentanil and meperidine, … Upton et al. 10found that large differences in the cerebral …
Recirculatory model of fentanyl disposition with the brain as the target organ
… cerebral kinetics of alfentanil, pethidine 7 and morphine 8 using a chronically instrumented
sheep … The cerebral pharmacokinetics was determined from simultaneous measurements of …
sheep … The cerebral pharmacokinetics was determined from simultaneous measurements of …
Comparison of cerebral pharmacokinetics of buprenorphine and norbuprenorphine in an in vivo sheep model
… the brain to be determined in conscious animals … morphine has been calculated to 1.4 (Upton
et al. Citation2003), indicating that norBUP has a higher brain tissue affinity than morphine …
et al. Citation2003), indicating that norBUP has a higher brain tissue affinity than morphine …
Blood–brain equilibration kinetics of levo‐α‐acetyl‐methadol using a chronically instrumented sheep preparation
DJR Foster, ML Jensen, RN Upton… - British journal of …, 2006 - Wiley Online Library
… , pharmacokinetic–pharmacodynamic modelling of LAAM should account for the large
equilibration delay between brain … (iv) infusion in conscious chronically instrumented sheep. Such …
equilibration delay between brain … (iv) infusion in conscious chronically instrumented sheep. Such …
The Acute Disposition of (R)- and (S)-Methadone in Brain and Lung of Sheep
… In conclusion, pharmacokinetic modelling of methadone confirmed a large equilibration …
The cerebral pharmacokinetics of meperidine and alfentanil in conscious sheep. Anesthesiology …
The cerebral pharmacokinetics of meperidine and alfentanil in conscious sheep. Anesthesiology …
A question of time
PJ Pascoe - Veterinary Anaesthesia and Analgesia, 2018 - vaajournal.org
… For example, in humans, the peak effect of alfentanil (partition … Models based on
pharmacokinetics have provided interesting … of induction of anaesthesia in sheep: variable …
pharmacokinetics have provided interesting … of induction of anaesthesia in sheep: variable …