[HTML][HTML] The critical role of histone lysine demethylase KDM2B in cancer
M Yan, X Yang, H Wang, Q Shao - American journal of …, 2018 - ncbi.nlm.nih.gov
M Yan, X Yang, H Wang, Q Shao
American journal of translational research, 2018•ncbi.nlm.nih.govThe discovery of histone demethylases has revealed the dynamic nature of the regulation of
histone methylation. KDM2B is an important histone lysine demethylase that removes methyl
from H3K36me2 and H3K4me3. It participates in many aspects of normal cellular processes
such as cell senescence, cell differentiation and stem cell self-renewal. Recent studies also
showed that KDM2B was overexpressed in various types of cancers. This review focuses
primarily on the current knowledge of KDM2B and its function in cancer development.
histone methylation. KDM2B is an important histone lysine demethylase that removes methyl
from H3K36me2 and H3K4me3. It participates in many aspects of normal cellular processes
such as cell senescence, cell differentiation and stem cell self-renewal. Recent studies also
showed that KDM2B was overexpressed in various types of cancers. This review focuses
primarily on the current knowledge of KDM2B and its function in cancer development.
Abstract
The discovery of histone demethylases has revealed the dynamic nature of the regulation of histone methylation. KDM2B is an important histone lysine demethylase that removes methyl from H3K36me2 and H3K4me3. It participates in many aspects of normal cellular processes such as cell senescence, cell differentiation and stem cell self-renewal. Recent studies also showed that KDM2B was overexpressed in various types of cancers. This review focuses primarily on the current knowledge of KDM2B and its function in cancer development.
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