The dimerization of methyl vanillate improves its effect against breast cancer cells via pro-oxidant effect

A de Souza Pessoa, CK Tokuhara, VS Fakhoury… - Chemico-Biological …, 2022 - Elsevier
Phenolic phytochemicals are a group of organic compounds with potent antioxidant features
but can also act as powerful pro-oxidants. These characteristics are effective in reducing
metastatic potential in cancer cells, and this effect has been associated with reactive oxygen
species (ROS). Methyl vanillate (MV) and its dimer, methyl divanillate (DMV), are potent
antioxidants. In the present study, we investigated the effects of MV and DMV on breast
cancer cell lines MCF-7 and MDA-MB-231 and compared the results using the non-tumor …
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