The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches

JA Lieberman, D Perkins, A Belger, M Chakos… - Biological …, 2001 - Elsevier
Schizophrenia is commonly considered a neurodevelopmental disorder that is associated
with significant morbidity; however, unlike other neurodevelopmental disorders, the
symptoms of schizophrenia often do not manifest for decades. In most patients, the formal
onset of schizophrenia is preceded by prodromal symptoms, including positive symptoms,
mood symptoms, cognitive symptoms, and social withdrawal. The proximal events that
trigger the formal onset of schizophrenia are not clear but may include developmental …
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