The effect of estradiol on COX-2, EP2, and EP4 mRNA expression and the extracellular matrix in the cervix of the hypogonadotrophic, ovariectomized ewe
CM Kershaw-Young, RJ Scaramuzzi, MR McGowan… - Theriogenology, 2010 - Elsevier
There is a degree of cervical relaxation in the ewe at estrus that is regulated by changes in
prostaglandin synthesis, prostaglandin receptor expression, and changes in the cervical
extracellular matrix. It is likely that these are regulated by changes in periovulatory
hormones, particularly estradiol. This study determined the effect of estradiol benzoate on
the mRNA expression of cyclooxygenase-2 (COX-2) and the prostaglandin E receptors EP2
and EP4, the concentration of cervical hyaluronan, and the proportion of smooth muscle and …
prostaglandin synthesis, prostaglandin receptor expression, and changes in the cervical
extracellular matrix. It is likely that these are regulated by changes in periovulatory
hormones, particularly estradiol. This study determined the effect of estradiol benzoate on
the mRNA expression of cyclooxygenase-2 (COX-2) and the prostaglandin E receptors EP2
and EP4, the concentration of cervical hyaluronan, and the proportion of smooth muscle and …
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