The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)
MJ Strong - Journal of the neurological sciences, 2010 - Elsevier
In this review, the role of aberrant RNA metabolism in ALS is examined, including the
evidence that a majority of the genetic mutations observed in familial ALS (including
mutations in TDP-43, FUS/TLS, SOD1, angiogenin (ANG) and senataxin (SETX)) can impact
directly on either gene transcription, pre-mRNA splicing, ribonucleoprotein complex
formation, transport, RNA translation or degradation. The evidence that perturbed
expression or function of RNA binding proteins is causally related to the selective …
evidence that a majority of the genetic mutations observed in familial ALS (including
mutations in TDP-43, FUS/TLS, SOD1, angiogenin (ANG) and senataxin (SETX)) can impact
directly on either gene transcription, pre-mRNA splicing, ribonucleoprotein complex
formation, transport, RNA translation or degradation. The evidence that perturbed
expression or function of RNA binding proteins is causally related to the selective …
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