Objective The aim of the study was to investigate the expression of ribonuclear protein IMP3
in laryngeal carcinogenesis, together with other biomarkers of carcinogenesis (Ki-67, p53
and cyclin D1), and to evaluate their predictive values. Methods The study included 153
patients divided into three groups: 68 operated for primary invasive laryngeal squamous cell
carcinoma (LSCC); 41 with precancerous lesions of atypical and abnormal hyperplasia; 44
with hyperplastic laryngeal nodule without atypia. Tissue microarray technique was used for …