To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529
individuals of European ancestry, and genotypes from an additional 140,886 individuals
were used for validation. We identified 66 blood pressure–associated loci, of which 17 were
new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for
cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary …

To dissect the genetic architecture of blood pressure and assess effects on target-organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529
individuals of European ancestry and genotypes from an additional 140,886 individuals
were used for validation. We identified 66 blood pressure loci, of which 17 were novel and
15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-
regulatory elements, particularly in vascular endothelial cells, consistent with a primary role …