The adverse reproductive outcomes of pesticide exposure in farmers are presented, emphasizing the severity of effects in developing countries. In case of male reproduction, pesticides may act through hormonal or genotoxic pathways, whereas in female, they may disrupt the hormonal function of the female reproductive system and in particular the ovarian cycle may result in modulation of hormone concentrations, ovarian cycle irregularities and impaired fertility. In conclusion, occupational exposures to pesticides particularly agricultural and horticultural occupations appear to have serious adverse effects on male and female reproduction. Farmers, especially those from less developed countries are in high exposure to pesticides and subsequently more chance for potential pesticide human reproductive issues.