The incidence of recurrence of leukemia in donor cells after allogeneic bone marrow transplantation
CN Boyd, RC Ramberg, ED Thomas - Leukemia research, 1982 - Elsevier
A total of 243 patients with acute leukemia received a marrow graft from a donor of the
opposite sex. Seventy-five patients subsequently relapsed, and specimens of the recurrent
leukemia cells were available for cytogenetic analysis in 54. Three relapses were in donor-
type cells. Four patients whose relapses were in host-type cells showed a cytogenic
abnormality that differed from the original leukemic clone. We conclude that a 'new'leukemia
in donor cells, and possibly in host cells, constitutes a small but significant fraction of …
opposite sex. Seventy-five patients subsequently relapsed, and specimens of the recurrent
leukemia cells were available for cytogenetic analysis in 54. Three relapses were in donor-
type cells. Four patients whose relapses were in host-type cells showed a cytogenic
abnormality that differed from the original leukemic clone. We conclude that a 'new'leukemia
in donor cells, and possibly in host cells, constitutes a small but significant fraction of …
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