The induction of cardiac hypertrophy by catecholamines can be dissociated from their inotropic effect
PG Carlier, RJ Gilles, NS Smelten… - Journal of …, 1988 - journals.lww.com
PG Carlier, RJ Gilles, NS Smelten, NM Yerna, GL Rorive
Journal of Hypertension, 1988•journals.lww.comIn this study, omithine decarboxylase, the first and rate-limiting enzyme of the polyamine
pathway, was used as a marker of the very early stages of cardiac hypertrophy. Our data
show that ornithine decarboxylase is independently regulated by ventricular wall stress and
adrenergic receptors, and support the theory that catecholamines have a pressure-
independent trophic effect.
pathway, was used as a marker of the very early stages of cardiac hypertrophy. Our data
show that ornithine decarboxylase is independently regulated by ventricular wall stress and
adrenergic receptors, and support the theory that catecholamines have a pressure-
independent trophic effect.
Abstract
In this study, omithine decarboxylase, the first and rate-limiting enzyme of the polyamine pathway, was used as a marker of the very early stages of cardiac hypertrophy. Our data show that ornithine decarboxylase is independently regulated by ventricular wall stress and adrenergic receptors, and support the theory that catecholamines have a pressure-independent trophic effect.
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