The major outer membrane protein OprG of Pseudomonas aeruginosa contributes to cytotoxicity and forms an anaerobically regulated, cation-selective channel
OprG of Pseudomonas aeruginosa is a member of the very large and widely distributed but
poorly characterized OmpW (PF0392) family of outer membrane proteins. It was established
here that OprG was highly transcribed in anaerobic environments rich in iron via the ANR
regulator. In the absence of OprG, P. aeruginosa was significantly less cytotoxic toward
human bronchial epithelial cells. Planar bilayer studies indicated that purified OprG formed
cationic-selective channels with a conductance of 500 pS in 1 M KCl; however, contrary to …
poorly characterized OmpW (PF0392) family of outer membrane proteins. It was established
here that OprG was highly transcribed in anaerobic environments rich in iron via the ANR
regulator. In the absence of OprG, P. aeruginosa was significantly less cytotoxic toward
human bronchial epithelial cells. Planar bilayer studies indicated that purified OprG formed
cationic-selective channels with a conductance of 500 pS in 1 M KCl; however, contrary to …
[PDF][PDF] The major outer membrane protein OprG of Pseudomonas aeruginosa contributes to cytotoxicity and forms an...
JB McPhee, M Bains, SL Gellatly, R Benz - 2009 - academia.edu
OprG of Pseudomonas aeruginosa is a member of the very large and widely distributed but
poorly characterized OmpW (PF0392) family of outer membrane proteins. It was established
here that OprG was highly transcribed in anaerobic environments rich in iron via the ANR
regulator. In the absence of OprG, P. aeruginosa was significantly less cytotoxic toward
human bronchial epithelial cells. Planar bilayer studies indicated that purified OprG formed
cationic-selective channels with a conductance of 500 pS in 1 M KCl; however, contrary to …
poorly characterized OmpW (PF0392) family of outer membrane proteins. It was established
here that OprG was highly transcribed in anaerobic environments rich in iron via the ANR
regulator. In the absence of OprG, P. aeruginosa was significantly less cytotoxic toward
human bronchial epithelial cells. Planar bilayer studies indicated that purified OprG formed
cationic-selective channels with a conductance of 500 pS in 1 M KCl; however, contrary to …
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