… If mutated in transgenic mice or if the cleaving enzyme, ovastacin, is genetically … zona
pellucida and, by genetic ablation, document that this domain is essential for female mouse fertility. …

… infertility characterized by oocytes with a thin zona pellucida (… truncating mutation in ZP1
was identified in infertile females … , for discussion of molecular genetics experiments. We thank …

… ASTL encodes ovastacin, which is known to trigger zona pellucida hardening (ZPH) as part
… zona pellucida proteins that result in a similar infertility phenotype in humans and mouse. …

… mutant female mice have been produced by homologous recombination in embryonic stem
cells. Mutant … fertility of female mice rely on ZP glycoprotein synthesis and the formation of a …

… produced Zpbp1 mutant and Zpbp1/Zpbp2 double mutant mice. … Globozoospermia is a rare
human infertility disorder … The Zpbp1 and Gopc infertile mouse models should promote our …

… However, two recent studies of male infertility found different NR5A1 missense mutations …
of the zona pellucida- and oocyte-specific genes. A knockout of FIGLA in female mice prevents …

… Baba T, Azuma S, Kashiwabara S, Toyoda Y (1994) Sperm from mice carrying a targeted
mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization. J …

… In mice, female mice lacking either ZP2 or ZP3 are unable to form a … Mutations in the
ZP2 gene and the ZP3 gene could also affect the zona pellucida and cause infertility, not only …

… mutation generated truncation of the ZP1 proteins, which may lead to primary infertility with
the failure of zona pellucida … -null mice produced oocytes with thinner, loosely organized zona …

… and lacked the zona pellucida (ZP). ZP3 is a major component of the ZP filament. When …
It has been demonstrated that female Zp3-deficient mice are completely infertile. Even though …