… Infertility can also result from fertilization failure, either due to oocyte maturation arrest and
the inability to produce a haploid zygote or to a defective zona pellucida… above mouse genes …

… with male infertility and often related to the mutation of the … is pushed through the zona
pellucida and the oolemma into the … With the advent of modern molecular genetics including …

… Herein, we report that ZP4 ablation impairs fertility in female … lacking a zona pellucida and
infertility in female mice. PNAS … Novel mutations in ZP1, ZP2, and ZP3 cause female infertility …

… The absence of MutB ZP3-EGFP incorporation into the zona pellucida of transgenic mice
suggested that the mutation resulted either in improper trafficking to the cell surface or failed …

… Thus, we anticipate that future genetic investigations will focus on infertile men with a … to
penetrate the zona pellucida. Further studies of mutant Zpbp2 mice demonstrated that aberrant …

… released to dissolve zona pellucida proteins during fertilization. … Male mice lacking SPAG6
are infertile because their sperm … sperm despite the fact that mutant sperm are misshapen and/…

… with different biological functions, whose mutations are linked to severe human diseases. …
-N moiety is highly similar to that of mouse, this section will discuss other ZP-C structures …

… genes known with mutations causing male infertility (AR; AZF … human male fertility genes
where mouse homologues exist … to penetrate the zona pellucida, causing infertility. Type II has …

… mice to explore effective approaches and contents of intervention for individuals carrying
mutations of female infertility … then gently injected under the zona pellucida of the enucleated …

… targeting the zona pellucida (Nishimura et al. 2019). … whose infertility phenotype resembles
that of Pabpc1l −/− mouse. … genes we found mutated in women with infertility in this study (…