… p53, and in some cases p63 and p73, induce apoptosis are … p53-regulated genes to
apoptosis induction by this protein, … between growth arrest and apoptosis by p53, p63 and p73, …

… involved in p53-induced cell death, we generated p53-inducible Saos-2 cells, a tumour cell
line … , we examined p53 protein levels in these cells. E1A-expressing wild-type MEFs showed …

… p53 induces either growth arrest, which prevents the replication of damaged DNA, or
programmed cell death (apoptosis), which is important for eliminating defective cells. Whether the …

… The p53 tumor suppressor gene is a sequence-specific transcription … of genes engaged
in promoting growth arrest or cell death in response to genotoxic stress. A possible role for p53-…

… When mammalian cells or tissues are exposed to DNA damaging agents a programmed
cell death pathway is induced as well as a cell cycle arrest. In mice in which the p53 gene has …

… in oncogene prompted cells (20), our results are consistent with the hypothesis that pX
sensitizes cells to p53-mediated programmed cell death and alters the cell response to DNA …

… Whereas some of the early studies relied on artificially exaggerated wt p53 function, 70,71 …
wt p53 protein in protection against cell death. How does p53 inhibit or delay apoptosis? The …

… gene implicated in the control of both cell division and programmed cell death is the p53
tumour suppressor gene… Located on the short arm of chromosome 17, p53 is inactivated in over …

… which the cell commits to programmed cell death. It has become clear, however, that under
some circumstances p53 can play a major role in the activation of cell death. Apoptosis has …

… of the reaper and sickle genes that have long been known to be required for programmed
cell death in Drosophila. The reaper gene product promotes death by inhibiting DIAP proteins, …